Action to Control Cardiovascular Risk in Diabetes (ACCORD) was a large clinical trial examining methods of lowering the rate of cardiovascular disease in adults with type two diabetes. The study was composed of three main clinical trials: an intensive lowering of blood sugar levels (Glycemia Trial), intensive lowering of blood pressure (Blood Pressure Trial), and treatment of multiple blood lipids...

This dataset was generated as part of a cluster-randomized, 2-arm trial to evaluate the effectiveness of a faith-based group-counseling therapeutic lifestyle intervention and motivational interviewed (MINT-TLC) vs. health education (HE) on black adults who attend churches in New York City. 32 churches with approximately 300 eligible adults were randomly assigned to either MINT-TLC or HE control, and...

This data was generated from a two-arm randomized controlled trial. The study evaluated the effectiveness of a culturally and linguistically tailored telephone-delivered intervention to promote adherence to physician-recommended sleep apnea assessment and treatment among black patients with metabolic syndrome. Outcomes of interest (diabetes mellitus, hypertension, and dyslipidemia) were assessed at...

This dataset was generated through a prospective randomized, double-blind study to determine the effects of serial phlebotomy on vascular endothelial function in the brachial artery. Subjects of the study were 84 iron-replete, non-anemia men and post-menopausal women age 40-70 years. Subjects were randomly assigned to three study treatment groups: Four serial phlebotomy procedures each followed by...

This dataset was collected as part of a double-blind, placebo-controlled, randomized clinical trial to determine the effects of intravenous rHuEpo (200U/kg daily for three consecutive days) on measures of platelet and endothelial cell activation, soluble Fas ligand, and peripheral blood mononuclear cell (PBMC) expression of angiogenesis signaling proteins. The study included 44 adults over 21 years...

The dataset contains data collected from twelve Balb/c mice with metastatic breast cancer (4T1 mammary tumors). Six mice were in the control group and six mice were treated with 5-Fluorouracil (5FU) for metronomic chemotherapy for two weeks. Diffusion MRI (dMRI) and Dynamic Contrast-enhanced MRI (DCE-MRI) images were collected at baseline and post-treatment. Immunohistochemically (IHC) stains and measurements...

The Colchicine Coronavirus SARS-CoV2 Trial (COLCORONA) was an international randomized double-blind controlled trial which investigated whether short-term treatment with colchicine decreased the rate of death, rate of hospitalization, and need for medical intervention among adult patients recently diagnosed with COVID-19. A secondary objective was to determine the safety of the intervention among a...

In a pilot open-label randomized controlled trial, investigators compared the effectiveness and acceptability of buprenorphine extended-release (XRB) drugs versus daily sublingual buprenorphine-naloxone (SLB) to treat opioid use disorders in adult prisoners during incineration and after community re-entry. Eligible participants met the following inclusion criteria: Over 18 years old Met Diagnostic...

Survey and clinical data were obtained from 570 participants in a randomized controlled trial to evaluate the comparative effectiveness of an extended release injectable naltrexone (XR-NTX, Vivitrol®) against buprenorphine-naloxone (BUP-NX, Suboxone®) as treatments for opioid dependence. The study was conducted in 8 NIDA Clinical Trials Network-affiliated community treatment programs in the United...

The Human Epilepsy Project (HEP) is a multi-institutional series of prospective, observational studies to identify factors that predict disease outcome, progression, and treatment response among participants with epilepsy. HEP, conducted between 2012 and 2020, included 488 participants aged 12 to 60 years old with new onset focal epilepsy recruited in Australia, Canada, and the United States. Participants...